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81377 München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Professor. Haass started to work on Alzheimer's disease (AD) hinein 1990 at a time, when very little welches known about the cellular mechanisms involved. Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß. Christian Haass hypothesized against the widely accepted general opinion rein this field that Aß may be produced from its precursor rein a physiologically gewöhnlich pathway and not necessarily hinein a pathological process. Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions. This pivotal finding was a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved hinein generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production in patients.
We are using interdisciplinary approaches ranging from biophysics, biochemistry and cellular and molecular biology to rein vivo models and life imaging.
My first driving lesson will take place in the winter when it is already dark. Does that count as night-driving? No. Your driving instructor is only allowed to give lessons hinein special driving situations towards the end of Weiterbildung (when you have acquired the necessary knowledge; but your first driving lesson with us will never take place at this time of the day!).
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Momo’s Driving School rein Munich also offers refresher courses for licence-holders World health organization want to optimise their driving skills or World health organization have not driven for a long time and want to gather practical driving experience accompanied by a driving instructor.
Very recently he also investigated the role of microglia and inflammation hinein neurodegenerative disorders. This work led to the spectacular finding that microglial phagocytosis may Beryllium impaired late during neurodegeneration and opened up a completely unexpected road towards new therapeutic developments for patients already developing disease symptoms. This work resulted hinein the identification of TREM2 as a CSF Weiterlesen marker for microglial activity. In a unique cohort of subjects with autosomal dominant AD, CSF sTREM2 welches abnormally increased 5 years before the expected onset of symptoms. This will not only greatly facilitate research on inflammatory disease overarching mechanisms, but may also provide a very valuable therapeutic marker.
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